Fluorescein Sodium

Indocyanine Green (ICG) – CAS No. 3599-32-4

Overview

Indocyanine Green (ICG) is a water-soluble, tricarbocyanine dye renowned for its near-infrared (NIR) fluorescence properties. With a peak absorption around 800 nm, ICG is extensively utilized in medical diagnostics, particularly for imaging vascular structures and assessing organ perfusion. Its strong affinity for plasma proteins ensures rapid distribution within the vascular system, making it an invaluable tool in various clinical settings.

Chemical Information

• Chemical Name: Indocyanine Green

• CAS Number: 3599-32-4

• Molecular Formula: C₄₃H₄₇N₂NaO₆S₂

• Molecular Weight: 774.96 g/mol

• Synonyms: Cardiogreen, IC Green, Foxgreen

• Appearance: Dark green to black powder

• Solubility: Soluble in water

• Storage Conditions: Store in a cool, dark place; protect from moisture and light

Pharmaceutical Applications

1. Cardiac Output Measurement: ICG is injected intravenously to determine cardiac output using indicator dilution techniques.

2. Hepatic Function Assessment: Due to its exclusive hepatic clearance, ICG is employed to evaluate liver function and hepatic blood flow.

3. Ophthalmic Angiography: ICG angiography is instrumental in visualizing the choroidal vasculature, aiding in the diagnosis of various retinal conditions.

4. Sentinel Lymph Node Mapping: In oncological surgeries, ICG assists in identifying sentinel lymph nodes, enhancing surgical precision.

5. Fluorescence-Guided Surgery: ICG’s fluorescence properties are harnessed to delineate tumor margins and assess tissue perfusion intraoperatively.

Mechanism of Action

Upon intravenous administration, ICG binds rapidly to plasma proteins, confining it to the vascular compartment. It is exclusively cleared by the liver into the bile without undergoing metabolism. The dye’s fluorescence under NIR light allows for real-time imaging of blood flow and tissue perfusion.

Regulatory Status

ICG is approved by various regulatory agencies, including the U.S. FDA, for specific diagnostic applications. Pharmaceutical-grade ICG should comply with compendial standards such as USP or Ph. Eur., ensuring quality and safety for clinical use.

Packaging and Availability

ICG is typically supplied as a lyophilized powder in sterile vials, commonly containing 25 mg per vial. It is reconstituted with sterile water for injection prior to use.

For procurement or more detailed information on Indocyanine Green suitable for pharmaceutical applications, consult us at nidcpl@gmail.com